Lividomycinの抗結核作用に関する基礎的研究

概要

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The experimental researches on antituberculous activity of a new antibiotics, Lividomycin (LVM) were carried out and the following results were obtained.<BR>1. The minimal inhibitory concentration of LVM against Mycobacterium tuberculosis was 0.5mcg/ml in Dubos liquid medium and 25-50 mcg/ml in Ogawas egg medium, which were almost as same as the MIC of KM. Tubercle bacilli resistant to SM, INH, PAS and RFP were susceptible to LVM. There was cross resistance between LVM and KM, but LVM was more susceptible than KM to KM resistant strains.<BR>2. Atypical Mycobacteria were usually not so susceptible to LVM, but a few strains were inhibited their growth by 1mcg/ml of LVM in Dubos liquid medium.<BR>3. Following intramuscular injection of 500 mg LVM given to man, maximum serum concentration of 23.5-37.8 mcg/ml were obtained after 1 hour.<BR>4. Evaluating by the survival days, in experimental tuberculosis of mice, LVM was equally effective as KM and SM.
日本結核病学会の論文