Rifampicin耐性に関する臨床的研究

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1. The investigation on the distribution of Rifampicin (RFP) resistant tubercle bacilliisolated from patients previously untreated with RFP. Out of 120 strains tested on Kirchner's semi-solid media, resistance to 0.5 mcg/ml RFP wasseen in 4 percent and 96 percent of strains was inhibited their growth on 0.5 mcg/ml RFP. The grade of resistant to RFP of 136 strains tested on Ogawa's media was as follows; 92.6 percent were sensitive, 5.2 percent incompletely resistant and 1.5 percent completely resistantto 10mcg/ml RFP. Only 1 strain (0.7%) was resistant to 25mcg/ml RFP. The susceptibility to RFP of 66 strains of atypical mycobacteria was tested on Ogawa'smedia, and 16 strains were sensitive to 10mcg/ml RFP and 44 strains showed resistance tomore than 50mcg/ml RFP. 2. The emergence of bacterial resistance to RFP in clinical observation. The resistance to RFP elevated to higher degree rapidly. Among cases considered to be RFP monotherapy because of the resistance to the other combined drugs, the rate of emergenceof resistance (more than 10mcg/ml RFP in Kirchner's semi-solid media) by month was asfollows; 2 nd month 54.5 percent; 4 th month 77.7 percent; 6th month 100 percent. Amongcases given RFP together with PZA or other sensitive drugs, appearance of RFP resistancewas as follows; 2nd month 31.5 percent; 4 th month 68.9 percent; 6th month 80.7 percent. In these resistant cases there were no clinical effects of RFP, and in all patients showingbacterial relapse during and after RFP treatment the appearance of resistance more than 10mcg/ml RFP on Kirchner's semi-solid media and more than 50 mcg/ml RFP on Ogawa's mediawere observed. As a controlled trial of RFP and PZA combined therapy, RFP was administered in thefollowing way; RFP 450 mg daily, RFP 450 mg twice weekly and 900mg twice weekly. Nosignificant difference was seen among three regimens in the time and rate of emergence of RFP resistance.
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Rifampicin耐性に関する臨床的研究

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