The Responses of Rat Intestinal Mucosa, Epithelial Cell Renewal and Plasma Lipoprotein to Intravenous Feeding

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Healthy young rats were fed on fat-free diets, 85% of the energy of which derived from glucose and 15% from amino acids. The composition of the intravenous infusates was adequate to maintain body weight during a 6-day experimental period. Mucosal wet and dry weight, and mucosal protein content were highest when the diet was given orally, intermediate when given intravenously, and lowest when fasting. The DNA content of mucosa was significantly lower following intravenous feeding or fasting than after oral feeding, and there was no significant difference between intravenous feeding and fasting. The composition of mucosal protein following intravenous feeding differed from that following oral feeding or fasting. The migration of jejunum epithelial cells was prolonged following intravenous feeding compared with that after oral feeding. The values of plasma albumin and glucose concentration showed no differences between the intravenous and oral feeding groups. In contrast, intravenous feeding greatly lowered the total plasma cholesterol, HDL-cholesterol and HDL-cholesterol/LDL-cholestrol ratio. LDLcholesterol levels were not changed.
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