The tissue distribution of L-ascorbic acid and dehydro-L-ascorbic acid in the guinea pigs injected intravenously with dehydro-L-ascorbic acid.

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概要

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• The tissue distribution of L-ascorbic acid (AsA) and dehydro-L-ascorbic acid (DAsA) in guinea pigs injected with DAsA intravenously was examined using high-performance liquid chromatog-raphy. DAsA injected into guinea pigs fed normal diets containing AsA (control group) was readily taken into erythrocytes, and AsA contents of plasma and other tissues rapidly increased after DAsA injection. In animals fed vitamin C-deficient diets, DAsA was also detected in eryth-rocytes; however, the increase of AsA in their tissues was considerably less than that of control group. From these results; it was suggested that utilization of DAsA as AsA in vitamin C-deficient guinea pigs was less than that of control animals, and the reduction mechanism of DAsA to AsA in vitamin C-deficient guinea pigs may have differed from that of control groups.

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著者

• 倉田 忠男

  Department of Food and Nutrition, 2 Institute of Environmental Science for Human Life, Ochanomizu University

• 大塚 惠

  Department of Food and Nutrition, Ochanomizu University

• 荒川 信彦

  Department of Food and Nutrition

関連論文

• Effect of Graded Doses of Erythorbic Acid on Activities of Drug Metabolic Enzyme and Phosphatases in Guinea Pigs
• Separative determination of ascorbic acid and erythorbic acid by high-performance liquid chromatography.
• Separative determination of ascorbic acid and erythorbic acid in animal tissues by high-performance liquid chromatography.
• An improved high-performance liquid chromatographic assay for the determination of free and esterified carnitine in animal tissues.
• Effect of erythorbic acid administration on activities of drug metabolic enzyme and phosphatases in guinea pigs administered an adequate amount of ascorbic acid.
• Effect of graded doses of erythorbic acid on ascorbic acid content of tissues of guinea pigs.
• Antiscorbutic effect of dehydro-L-ascorbic acid in vitamin C-deficient guinea pigs.
• Effect of erythorbic acid administration on ascorbic acid content in guinea pig tissues.
• The tissue distribution of L-ascorbic acid and dehydro-L-ascorbic acid in the guinea pigs injected intravenously with dehydro-L-ascorbic acid.
• The effect of graded doses of ascorbic acid on the tissue carnitine and plasma lipid concentrations.

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