Antiscorbutic effect of dehydro-L-ascorbic acid in vitamin C-deficient guinea pigs.

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概要

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• The antiscorbutic effect of dehydro-L-ascorbic acid (DAsA) was investigated in vitamin C-deficient guinea pigs. Male guinea pigs were fed vitamin C-deficient diets for 16 days to deplete body L-ascorbic acid (AsA) pools and then fed the deficient diet supplemented with DHA and/or AsA intraperitoneally for 14 days. During the repletion period, most of the animals injected with 0, 5mg DAsA/day developed scurvy, their body weights decreased and their mortality rate was higher than that of the other groups injected with 0.5mg AsA/day or 5mg DAsA/day. Injecting animals with 0.5mg AsA/day resulted in the disappearance of the typical scorbutic symptoms and regaining of body weight. These data indicate that DAsA has considerably less antiscorbutic activity than AsA in vitamin C-deficient guinea pigs.

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著者

• 倉田 忠男

  Department of Food and Nutrition, 2 Institute of Environmental Science for Human Life, Ochanomizu University

• 大塚 惠

  Department of Food and Nutrition, Ochanomizu University

• 荒川 信彦

  Department of Food and Nutrition, 2 Institute of Environmental Science for Human Life, Ochanomizu University

関連論文

• Effect of Graded Doses of Erythorbic Acid on Activities of Drug Metabolic Enzyme and Phosphatases in Guinea Pigs
• Separative determination of ascorbic acid and erythorbic acid by high-performance liquid chromatography.
• Separative determination of ascorbic acid and erythorbic acid in animal tissues by high-performance liquid chromatography.
• Effect of erythorbic acid administration on activities of drug metabolic enzyme and phosphatases in guinea pigs administered an adequate amount of ascorbic acid.
• Effect of graded doses of erythorbic acid on ascorbic acid content of tissues of guinea pigs.
• Antiscorbutic effect of dehydro-L-ascorbic acid in vitamin C-deficient guinea pigs.
• Effect of erythorbic acid administration on ascorbic acid content in guinea pig tissues.
• The tissue distribution of L-ascorbic acid and dehydro-L-ascorbic acid in the guinea pigs injected intravenously with dehydro-L-ascorbic acid.
• The effect of graded doses of ascorbic acid on the tissue carnitine and plasma lipid concentrations.

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