Effect of graded doses of erythorbic acid on ascorbic acid content of tissues of guinea pigs.

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The effect of graded doses of erythorbic acid (ErA) on the content of ascorbic acid (AsA) in the tissues of guinea pigs administered AsA was studied. The guinea pigs were administered 5mg AsA and 1, 5, 20, and 100mg ErA; or 1 mg AsA and 1 and 20mg ErA; or 20mg AsA and 20mg ErA for 16 days. The animals were then sacrificed, and the liver, adrenal glands, spleen, and kidneys were removedd to determine the contents of AsA and ErA by using HPLC. The content of AsA in the tissues of the animals administered less than 5mg ErA together with 5 mg AsA was not significantly different from that of the animals administered 5mg AsA. The administration of 100mg ErA together with 5 mg AsA caused a decrease in the amount of AsA in the tissues. The content of AsA in the tissues of the animals administered ErA together with 1 mg AsA was not significantly different from that of the animals administered 1mg AsA. In the case of animals administered an equal amount of both AsA and ErA, the AsA tissue content was consistently much higher than that of ErA. These results indicated that the administration of relatively small amounts of ErA did not appear to reduce the availability of AsA.
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