Preoperative and postoperative combination chemotherapy with low dose MTX5-FU for oral cancer.

概要

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A new intensive methotrexate-5-fluorouracil regimen (MF therapy) prior to surgery and posterior to the treatment of advanced squamous cell carcinoma of the head and neck is presented, employing twice-weekly parenteral low doses of methotrexate, once-weekly parenteral low doses of 5-fluorouracil and parenteral doses of leucovorin 24 hours following methotrexate. Toxicity and therapeutic results in patients treated with this regimen compare favorably with results of weekly administration of high-dose methotrexate.<BR>Partial response (PR) was observed in five of seven cases (71%) treated on the intensive low dose schedule. Two cases showed minor responses (MR).<BR>All patients are alive and have no recurrence. This initial chemotherapy is highly effective in the treatment of this group.
社団法人日本口腔外科学会の論文