ニフェジピンおよびニフェジピンとシクロスポリンの併用により発症したと思われる歯肉増殖症の2例

概要

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Two cases of gingival hyperplasia induced by nifedipine and both nifedipine and cyclosporine were presented. In a 46 year old woman, gingival hyperplasia developed 1 year and 1 month after nifedipine administration. Gingival hyperplasia covered lower 1/3 of dental crown and was not seen in the edentulous portion. In a 47 year old man, gingival hyperplasia had not been observed during 4 years after nifedipine administration. It occurred 1 year and 4 months after administration of both nifedipine and cyclosporine due to renal transplantation. Additive effects of nifedipine and cyclosporine were considered in the latter case. Reported cases of gingival hyperplasia induced by nifedipine and/or cyclosporine were reviewed. First choice of treatment is change of drugs and plaque control and then gingivectomy should be chosen, if no improvement is found after a few months observation.