口腔扁平上皮癌患者に対する術前MF療法の検討

概要

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Twenty-five patients with oral squamous cell carcinomas were treated initially with methotrexate 75mg/body followed 1 hour later by 5-fluorouracil 500 mg/body twice a week. Treatments were repeated every 7 days for 2 weeks. 1. Of 25 evaluable patients with squamous cell carcinoma, 17 (68%) achieved a partial (12) or complete (5) response, and 4 (16%) achieved minor response. 2. Histopathological effect was found in 18 (72%) patients. 3. Down-Stage rate was 72%. 4. Clinical effect for cervical lymph nodes metastases was 75%, and in 2 out of 8 patients cervical lymph node metastases disappeared histopathologically. 5. The recurrence rate of primary lesions was 12%, the metastasis rate of cervical lymph node was 8%, the distant metastasis rate was 4%, and the total recurrence and/or metastasis rate was 24%. 6. Side effects were slight, and severe leukopenia, mucositis, and kidney disorders were not observed. 7. The 5 year survival rate was 74.7%, and it was higher than that of surgery alone (58.4%) and that of preoperative radiotherapy-surgery (55.5%). This observation suggests that patients with oral squamous cell carcinoma were sensitive to initial MTX/5-FU therapy (MF therapy) and preoperative chemotherapy provide a good prognosis.