Effect of afloqualone (Arofuto) on tonic vibration reflex of the masticatory muscle.

概要

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The authors examined the efficacy of afloqualone (Arofuto<SUP>®</SUP>) a centrally acting muscle reluctant, on the neuromuscular system of mastication, by monitoring the magnitude of biting force exerted from a tonic vibration reflex of the masticatory muscles, particularly the masseter. The reflex was evoked by a mechanical vibration given to the muscle. Afloqualone (40mg) was orally administered to 10 healthy adult volunteers for this examination.<BR>The mean magnitude of the biting force was significantly reduced from 7.2kg before administration, to 5.0, 3.5 and 5.4kg at 30, 60 and 120 minutes, respectively, after the administration (P<0.01). This result seems to indicate that the use of afloqualone may be of value to patients in acute myofascial pain dysfunction syndrome.
社団法人日本口腔外科学会の論文