Study on multiphase biomedical materials compatible with bone tissue. Part 3. A cell culture test of hydroxyapatite-polymer composite material.:Part 3. A cell culture test of hydroxyapatite-polymer composite material

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Implant materials which serve as substitutes for hard tissues such as teeth and mandibles must satisfy many criteria including biochemical compatibility, biomechanical compatibility, and ease of processing and handling. The authors et al. have developed multiphase materials consisting of hydroxyapatite [HAP] particles (8μ or 7μ average diameter), poly (2, 2, 2-trifluoroethyl methacrylate)(PTFEMA) or poly (methyl methacrylate)[PMMA] around a metal core in order to obtain an implant material which easily satisfies all the proposed criteria. The purpose of this study is to evaluate the biochemical compatibility of these multiphase materials. HAP-70 wt% polymer composite materials were placed on the interfacial layer of multiphase materials in direct contact with living tissue. In order to evaluate biochemical compatability, the HAP-polymer composite was examined using a direct contact method cell culture test which measured cytotoxity and cell adhesiveness. As controls, both homopolymers of PTFEMA and PMMA, and HAP dense ceramics were also examined. Consequently, (1) Neither PTFEMA nor PMMA demonstrated cytotoxity, but each tended to require more time for cell spreading and cell growth on the surface than HAP dense ceramics. (2) HAP dense ceramics showed high degrees and rates of cell adhesiveness and growth. (3) Both HAP-polymer composite materials, containing either PTFEMA or PMMA showed essentially the same cell adhesiveness and growth pattern as HAP dense ceramics. These results indicate the safety and suitability of these multiphase materials for use as implant materials when hard tissue substitutes are required.

Study on multiphase biomedical materials compatible with bone tissue. Part 3. A cell culture test of hydroxyapatite-polymer composite material.:Part 3. A cell culture test of hydroxyapatite-polymer composite material

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