口腔白板症, 扁平上皮癌におけるEGF受容体の免疫組織学的検討

概要

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Epidermal growth factor receptor (EGF-R) expression was immunohistochemically investigated on biopsied materials of non-treated 28 oral leukoplakias and 62 oral squamous cell carcinomas (SCC). In leukoplakias (histopathologically graded to I-IV), the stainability was evaluated on the diseased portion and its neighboring healthy epithelium, and in SCC comparative evaluation of EGF-R stainability was performed on three portions of the sections, i. e. healthy epithelium, intermediately neighboring epithelium (atypical/hyperplastic/in situ carcinoma) and invasive region. Epithelia of healthy portions were reacted with the antibody in about 60% of the sections, and both basal and lower spinous layer cells were more intensively stained. EGF-R stainability did not increase in pathological region of OLP, and no difference of staining intensity between healthy and pathologic portion, and also among grade I-IV, could be found. In SCC, no clear different staining could be obtained among three portions. These results may indicate that increase of the receptor on cancer or hyper/dysplastic cells, if it occurs, might be insufficient to exhibit increasement of the immunostainability. Lymphnode metastasis was, however not so strict, statistically significantly correlated with the staining intensity, but EGF-R stainability did not related with cellular differentiation or atypia.