A clinical investigation on the patients who died of a malignancy in the jaws and oral cavity.

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We clinically analysed 58 patients who had died out of 168 cases of jaw and oral malignancies. When limited to tumor death, 21 patients of 138 squamous cell carcinomas (SCC), 4 of 22 salivary gland tumors (SGT), all of the 5 malignant lymphomas and 2 melanomas died of local invasion or metastasis. Except for tumor death, there were lethal cardiovascular diseases which composed of cerebral infarction in 9, cerebral bleeding in one and cardiac infarction in 4 cases, and also there were lethal respiratory disorder (pneumonia) in 4, secondary cancer in 6, unknown diseases in 2 and naturaldeath in 5 cases. The mean survival months were 25.2±19.4 in SCC and 40.2±26.5 in SGT. Inmost of those who died of cardiovascular diseases, complications such as heart disorders, hypertension, and diabetes mellitus were found before and during hospitalization. In SCC, the advanced tumors such as T3 and T4 with N2 or N3 sometimes insufficiently reacted tothe chemo/radiotherapy, and the mortality in those cases was extremely higher than thatin the earlier stage tumors. Local advancement, lymph node and distant metastasis caused deathin 9, 6 and 4 SCC cases, respectively. Compared with SCC, SGT showed a higher frequency of distant metastasis. These results indicate that advanced SCC resulting in insufficient tumor remission by induction therapy remains in a position to receive more effective approaches, and that distant dissemination of adenoid cystic carcinoma cells is of long term sequence. The present study also indicates that prevention of lethal secondary malignancies and cardiovascular diseases early detecting their associated risk factors by way of careful observation and routine laboratory examinations is important after discharge.
社団法人日本口腔外科学会の論文

A clinical investigation on the patients who died of a malignancy in the jaws and oral cavity.

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