舌癌治療後12年を経て頸部リンパ節に後発転移のみられた1例並びに口腔扁平上皮癌後発転移例の潜伏期についての検討

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The patient, 67-year-old female, was found to have a cervical lymph node metastasis after 12-year radiation therapy for the tongue cancer (T2N0M0, squamous cell carcinoma). Histological grading of malignancy (Jakobsson, 1973) of the primary tumor was a moderate type with marked cellular response. Radical neck dissection was performed and examined histologically. Metastasis was observed only in one lymph node and the paracorcical area of the lymph node revealed hypertrophy.<BR>The patient has been followed for 1 year postoperatively. She is now free of the disease. A possible factor in the patient with a long-delayed metastasis is considered to he an "abscopal effect" following radiation therapy for the primary tumor using a radium needle (76.4Gy/168 hr.).<BR>Additionally, late development of metastases of oral squamous cell carcinoma are discussed on the basis of data from our series.
社団法人日本口腔外科学会の論文