Electron microscopical study of endothelial cells on early healing process in tooth extraction wounds.

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The vascularization is an important factor along with the wound healing process, and there are some reports on extraction wounds. However, the ultrastructure of newly developed capillaries in the healing process is still argued. It is aimed of clearing the ultrastructural early healing process of endothelial cells in the experimental tooth extraction wound by electron microscopy.<BR>Immediately after the extraction, the diffused basal lamina intermittently surrounded endothelial cells. Three days after the extraction, the basal lamina was not continuous, but had no gap with endothelial cells. Four days after the extraction, the basal lamina almost reconstructed.<BR>On tannic acid injection into blood vessels, it was observed in the narrow lumen of cell masses which continued to capillaries. It is suggested that cell masses are derived from the endothelial cells, and are the precursor of capillaries.<BR>The cell masses were formed by two or three undifferentiated endothelial cells. The narrow lumen was observed in the cell mass and these cells project short folds into the lumen. These cells connected by tight junctions, but the basal lamina was not complete. On tannic acid injection, it does not perfuse into the stroma through the basal lamina. It is concluded that these types of connections between the endothelial cells, were one of the characteristic features of capillaries in the tooth extraction wound.
社団法人日本口腔外科学会の論文