顎口腔領域にみられた Histiocytosis Xの電顕的, 免疫組織化学的観察

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Histiocytosis X (HX) arising in the oral and maxillofacial region is relatively rare. Here, two cases of HX, i.e., Hand-Schaller-Christian disease (HSC) and Eosinophilic granuloma of bone which occurred in the oral and maxillofacial region are presented with immunohistochemical, light and electronmicroscopic studies.<BR>Case 1: a 37-year-old male was referred to our hospital, with the chief complaint of difficulty in chewing and radiolucent lesions in the bilateral mandible. Pathological examination revealed Eosinophilic granuloma of bone.<BR>Case 2: a 23-year-old male was admitted to our hospital because of the mobility of the front teeth in the mandible. He had received treatment for HSC since he was 1 year and 6 months old.<BR>Electronmicroscopic observations showed a number of proliferated histiocytic cells in both cases and these cells seemed to be Langerhans cells.<BR>In the HSC of which the clinical activity seemed to be higher than that of Eosinophilic granuloma, a number of small Birbeck granules were found as compared with in the Eosinophilic granuloma.
社団法人日本口腔外科学会の論文