舌扁平上皮癌における各種パラメーターと原発部再発およびリンパ節転移との関連について

概要

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The relationship between histological grade, mode of invastion, DNA ploidy, and PCNA positive rate to the recurrence of primary tumors and cervical lymph node metastases was investigated in 33 cases of tongue squamous cell carcinomas. No significant relationship was observed between the occurrence of primary recurrence and any of the four variables, although the rate of recurrence was slightly higher in case showing a PCNA positive cell rate of more than 30%. In contrast a significant relationship was noted between the incidence of cervical lymph node metastasis and the mode of invasion (p<0.01), DNA ploidy (p<0.05), and rate of PCNA postive cells (p<0.05). In addition, cervical lymph node metastases were noted in 5 of 7 cases that fulfilled at least two of following three carditions: diffuse invasion, DNA aneuploidy, and a PCNA positive cell rate of more than 30%. Secondary metastases desfite control of the primary lesion were noted in 3 of these 5 cases (60%).<BR>These results suggest that the above three factors related to cervical lymph node metastasis can be used to analyse the relative risk of secondary metastasis in squamous cell carcinomas of the tongue.
社団法人日本口腔外科学会の論文