Excessive Expression of Hippocampal Ezrin Is Induced by Intrastriatal Injection of 6-Hydroxydopamine
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概要
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Accumulating evidence in humans demonstrates that visuo-spatial deficits are the most consistently reported cognitive abnormalities in Parkinsons disease (PD). Ezrin, radixin, and moesin are collectively known as ERM proteins. Although ERM proteins have important implications in cell-shape determination and relevant signaling pathway, they have not been studied in the hippocampus in association with visuo-spatial memory impairments. The purpose of the present study is to examine whether the expression level of ERM proteins in the hippocampus is changed by an intrastriatal injection of 6-hydroxydopamine (6-OHDA) in mice. The intrastriatal injection of 6-OHDA induced partial dopaminergic deficits and spatial memory impairments. We also found that ezrin was increased in the hippocampus by the microinjection of 6-OHDA. On the other hand, protein levels of radixin and moesin were not influenced by 6-OHDA lesions. These results suggest that excessive ezrin may be related to visuo-spatial memory impairments.
- 公益社団法人 日本薬学会の論文
著者
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Asano Shinji
Department Of Molecular Physiology College Of Information Science And Engineering Ritsumeikan Univer
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Yoshimoto Kanji
Department Of Forensic Medicine Kyoto Prefectural University Of Medicine
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Murakami Hiroki
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Matsumoto Yosuke
Department Of Hematology/oncology Kyoto Prefectural University Of Medicine
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Hattori Naoki
Clinical Pharmacology Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University
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Inden Masatoshi
Clinical Pharmacology Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University
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Murakami Hiroki
Department Of Food Science And Technology And Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Murakami Hiroki
Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University
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Murakami Hiroki
Department of Analytical and Bioinorganic Chemistry, Division of Analytical & Physical Sciences, Kyoto Pharmaceutical University
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Matsumoto Yosuke
Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
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