微生物に対するpyridoxine phosphatesの活性

概要

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The procedure to prepare pure pyridoxine phosphates (PIN-4-P, PIN-5-P) was established and was reported in a previous paper. Then we attempted to determine the comparative activity, to certain strains of microorganisms, of pyridoxine (PIN), pyridoxal (PAL), pyridoxamine(PAM), pyridoxal-phosphate (PAL-P), and pyridoxamine phosphate (PAM-P), since the data including PIN-P activity to these microorganisms could not be found in the paper which described Vitamin B6 activity. Four strains of microorganisms, Sacch. carlsbergensis, Sir. faecalis R., Lact. casei and Lact. acidophilus, were adopted for use in the estimation of the comparative activity of PIN-P. For Sacch. carlsbergensis, PIN-5-P showed the same activity as PIN but it was superior to PAL-P and PAM-P. For Sir. faecalis R., PIN-5-P was 16 times more active than that of PIN but it was still less active than that of PAL, PAM and their phosphates. For Lact. casei, PIN-P was in similar activity to PIN and lower than that of PAL and PAL-P. For Lact. acidophilus, PIN-5-P brought out significant activity, but it was inferior to PAL-P and PAM-P, where, as PIN, PAL and PAM had no activity. PIN-4-P showed generally less activity than that of PIN-5-P for all four strains used.
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