Screening for Microbial Metabolites Affecting Phenotype of Caenorhabditis elegans
スポンサーリンク
概要
- 論文の詳細を見る
Microbial samples, including our library of known microbial compounds (ca. 300) and microbial culture broths (ca. 9000), were screened for small molecules affecting the phenotype of Caenorhabditis elegans. As a result, seven known compounds were found to induce phenotypic abnormality of C. elegans. Staurosporine exhibited morphological defects in the vulva and tail of C. elegans, avermectin B1a exhibited hatching inhibition of starting eggs on day 1 at 25—100 μM and growth inhibition at 0.01—12.5 μM, siccanin and antimycin A inhibited the growth of C. elegans, and fluorouracil inhibited hatching of eggs newly spawned by adult C. elegans. Toromycin induced morphological defects in the intestine. 5-(4-Methoxyphenyl)-oxazole, isolated as a fungal metabolite for the first time, inhibited the hatching of eggs newly spawned by adult C. elegans.
- 公益社団法人 日本薬学会の論文
著者
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TOMODA Hiroshi
Graduate School of Pharmacy, Kitasato University
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Takahashi Yoko
Kitasato Institute for Life Sciences, Kitasato University
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Takada Y
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takahashi Yoko
Kitasato Institute For Life Sciences Kitasato University
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MASUMA Rokuro
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato Unive
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Tanaka Y
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Uchida R
The Kitasato Institute
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Taniguchi Y
Kitasato Institute For Life Sciences Kitasato University
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Tanaka Y
Research Center For Biological Function
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Yamamuro Daisuke
Graduate School of Pharmaceutical Science, Kitasato University
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Uchida Ryuji
Graduate School of Pharmaceutical Science, Kitasato University
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Tomoda Hiroshi
Graduate School Of Pharmaceutical Sciences Kitasato University
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Takahashi Yoko
The Kitasato Institute
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Tomoda Hiroshi
Graduate School Of Pharmaceutical Sciences Kitasato Univ.
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Masuma Rokuro
Kitasato Institute for Life Sciences, Kitasato University
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Takahashi Yoko
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University
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Tomoda Hiroshi
Graduate School of Pharmaceutical Science, Kitasato University
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Takahashi Yoko
Kitasato Instit. Life Sci., Kitasato Univ.:Grad. Sch. Infect. Con. Sci., Kitasato Univ.
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