6′-Hydroxy-3′-methoxy-mitorubrin, a New Potentiator of Antifungal Miconazole Activity, Produced by Penicillium radicum FKI-3765-2
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概要
- 論文の詳細を見る
A new mitorubrin congener designated 6′-hydroxy-3′-methoxy-mitorubrin (1) was isolated along with structurally related 4′-hydroxy-3′-methoxy-(S)-mitorubrin (2) and monomethyl-(S)-mitorubrin (3) from the culture broth of Penicillium radicum FKI-3765-2 by solvent extraction, octadecyl silyl (ODS) column chromatography and HPLC. The structure of 1 was elucidated by various spectral analyses, including NMR experiments. They have a common isochromane-like ring with a similar hydrophobic side chain. These compounds moderately potentiated miconazole activity against Candida albicans.
- 公益社団法人 日本薬学会の論文
著者
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TOMODA Hiroshi
Graduate School of Pharmacy, Kitasato University
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OMURA Satoshi
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato Uni
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Omura Satoshi
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Yamazaki Hiroyuki
Graduate School of Pharmaceutical Sciences, Kitasato University
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Tomoda Hiroshi
Graduate School Of Pharmaceutical Sciences Kitasato University
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Tomoda Hiroshi
Graduate School of Pharmaceutical Science, Kitasato University
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Tomoda Hiroshi
Graduate School of Pharmaceutical Sciences, Kitasato University
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Ōmura Satoshi
Kitasato Institute for Life Sciences, Kitasato University
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Omura Satoshi
Kitasato Institute
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Yamazaki Hiroyuki
Graduate School of Pharmaceutical Sciences, Chiba University
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