特発性炎症性腸疾患の発症, 再燃に対する喫煙の影響

概要

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In order to investigate the influence of smoking upon the onset and relapse of ulcerative colitis (UC) and Crohn's disease (CD), a case-control study was performed on 111 patients with UC and 25 patients with CD.Patients were divided into non-smokers (NS), ex-smokers (ES) and smokers (S) by smoking habits at the onset of the disease. Relative risk (RR) and dose-response relationship (DRR) were studied in each groups.It was revealed that RR of UC was 0.89 in ES (not significant), and 0.50 in S (p<0.001). Negative DRR was shown between the quantity of cigarettes smoked daily and RR of UC, and RR of UC decreased significantly (p<0.01) in patients who smoked more than 21 cigarettes daily. RR of CD was 0.53 (not significant), and DRR was not observed.These results suggest that smoking might be a low risk factor for the onset of UC, and no association between smoking and the onset of CD was shown.