A pathohistological study on the fibrosis of the recurrent gastric ulcer: in order to analyze the growth pattern of gastric cancer accompanying peptic ulcer.:In Order to Analyze the Growth Pattern of Gastric Cancer Accompanying Peptic Ulcer

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A histological study on natural history of fibrosis found in peptic ulcer of the stomach was made upon initial type ulcers (34 round ulcers) and recurrent type ulcers (51 ulcers recurring adjacent to the ancient ulcer scar and 6 linear ulcer scars), as a preliminary work for analyzing growth pattern of the gastric cancer with peptic ulcer in itself. To evaluate the expanse of fibrosis, ratio of F-sm (area of submucosal fibrosis) and F-ss (area of subserosal fibrosis), i.e., F-sm/F-ss was used as a parameter. Average value of F-sm/F-ss of recurrent ulcers was significantly smaller than that of round ulcers (p<0.001). This is because preexistent fusion of two muscle layers in ancient ulcer scar has a blocking effect on the expansion of recurrent submucosal fibrosis. Average value of F-sm/F-ss of ancient linear ulcer scar did not show significant difference from that of ancient round ulcer scars. So it suggests that recurrent fibrosis is also absorbable and gradually decreases in amount as time passes as well as that of initial round ulcer. We tried to identify the site of recurrent ulcer histologically, by using F-classification which is the morphological and chronological classification of fibrosis previously reported, and F-classification was available only for the identification of a recurrent ulcer which had occurred within a year after onset.
財団法人日本消化器病学会の論文