:With Special Reference to ultrastructural Findings of the Liver

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Clinical features and histological studies of the liver were described in 6 patients with porphyria cutanea tarda. Patients were all men, age ranging from 41 to 61 years old. All patients had significant alchohol beverage, more than 80g per day for 15 to 35 years.The urinary and fecal excretions of porphyrins were increased in all cases. The peritoneoscopic findings revealed that on the liver surface there were blue spots at the site corresponding to the acinaous marking. Furthermore, typical red fluorescence was observed in liver specimen in all cases. Histologically, there were needle-like inclusion bodies present in the cytoplasma, which were recognized as the third type by electron microscopy. Smooth endoplasmic reticulum appeared hypertrophied and proliferated. Mitochondria were deformed and swollen. The most conspicuous and consistent finding was the presence of paracrystalline inclusion bodies and large electron-dense granules located in the mitochondria.
財団法人日本消化器病学会の論文