Diagnostic prospect of drug induced liver injury and NANB hepatitis using multivariate analysis.

概要

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In order to make a differenciation of drug induced liver injury from posttransfusion NANB hepatitis, discriminant analysis and theory of quantification were used. Discriminant function was obtained by factors such as GOT, total cholesterol, age, numbers of eosinophils in peripheral blood, TTT and ALP which were selected by stepwise method. According to this discriminant function, 31 (88.6%) of 35 with drug induced hepatitis and 33 (89.2%) of 37 with posttransfusion NANB hepatitis were correctly discriminated. In theory of quantification, discriminant function was obtained from 16 quantative and qualitative parameters. According to the discriminant function, 31 (91.2%) of 34 with drug induced liver injury and 34 (97.8%) of 35 were correctly differenciated. Partial correlation coefficients showed that the most available parameters for discrimination was GOT and followed by numbers of eosinophils, jaundice, gamma-globulin, total cholesterol and fever in this order. If external check for another 13 cases was performed, 84.6% and 92.8% was correctly differenciated by discriminant analysis and theory of quantification, respectively. This result was similar to that of internal check.
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