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Pathological examination of the pancreas was done on 6 autopsied cases with Sjogren's syndrome. All cases showed mild to moderate histological changes of the pancreas.Of these changes, acinar atrophy and oncocytic change of acinar and duct cells, were commonly seen and found in 4 of 6 cases. Interstitial lymphocytic infiltration was found in 3 cases, and another findings were interstitial fibrosis, acinar ectasis with eosinophilic plug, and parenchymal fatty infiltration.The analysis of relation-ship between the lesion of salivary gland and pancreatic involvement demonstrated that the cases with stage III or IV in sialogram tended to have various lesions in the pancreas.This study suggests that the pancreas may be involved in Sjogren's syndrome.
財団法人日本消化器病学会の論文