PANCREATIC INVOLVEMENT OF SJÖGREN'S SYNDROME

概要

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Pancreatic involvement of 38 patients with Sjögren's syndrome was examined.Ten among 29 patients revealed abnormal findings in PS test and 5 among 13 in ERCP. These abnormalities were mild, however, not correlative to the stage of sialogram, and observed in the patients over the fifth decade in age.Beta 2 microglobulin concentration in pancreatic juice of the patients with Sjögren's syndrome was slightly elevated compared to that of control patients.The analysis of serum amylase isozyme demonstrated markedly low level of salivary type amylase in the patients with advanced changes in sialography, suggesting positive correlation between the concentration of serum salivary type amylase and the histological changes in the salivary glands.This study might suggest that the pancreas might be involved in the disease process of Sjögren's syndrome.
財団法人日本消化器病学会の論文