:Effect of Colchicine on the Absorption of Long Chain Fatty Acids and the Role of Intestinal Alkaline Phosphatase
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study is to assess the re of microtubules in the process of absorption and transportation of long chain fatty acids into intestinal lymph and to clarify whether intestinal alkaline phosphatase (IAP) plays a part in the phase of lipoprotein release to lymphatics during fat absorption.Male Wistar rats provided with intestinal lymph fistula were used for the absorption studies. Mixed micellar solutions of fatty acids were administered into the duodenum of rats. Effect of colchicine, an inhibitor of microtubular function, on the fatty acid absorption and alkaline phosphatase activity during fat absorption were studied in intestinal lymph.In colchicine-treated rats, the lymphatic absorption of intraduodenally administered long chain fatty acids was decreased, however, there was no significant difference of colchicine inhibition between the lymphatic absorption of palmitic acid (saturated) and linoleic acid (unsaturated). Administered fatty acid was transported slowly to lymphatics almost in form of free fatty acid when colchicine was treated. Microtubular system was revealed to be necessary for the lipoprotein release from intestinal epithelial cells to lymphatics during fatty acid absorption.In control rats, the increased activity of TAP in intestinal lymph was observed in parallel with the amount of absorbed fat. However, in colchicine-treated rats, the equal amount of output of TAP to lymphatics was also observed in spite of the decrease of linoleic acid absorption. These results suggest that microtubular system does not take part in the transportation of TAP into lymphatics and TAP may not play a possible role in the phase of secretion of lipoprotein from intestinal epithelial cells during the absorption of long chain fatty acid.
- 財団法人 日本消化器病学会の論文
著者
関連論文
- 17. 胃粘膜下に転移を認めた肺大細胞癌の 1 例(第 39 回関東気管支研究会)
- 分泌性下痢--発生機序に関する新しい見解
- 腸粘膜病変形成における Nitric oxide synthase (NOS), Endothelin の変動
- 慢性エタノール投与における肝細胞および Kupffer 細胞の Nitric oxide synthase(NOS) 活性の検討
- 吸収不良症候群をめぐって
- Peyer板と局所免疫
- 特異な血清胆汁酸分画異常を示し, 胆管炎併発時にCA19-9異常高値を呈した原発性硬化性胆管炎の1例
- Klebsiella oxytoca 及び Clostridium innocuum を検出した偽膜性大腸炎の1例
- 腸管における消化,吸収のメカニズム 脂肪,胆汁酸,ビタミン類
- 腸管リンパよりみた脂肪吸収転送過程 : 長鎖飽和脂肪酸と長鎖不飽和脂肪酸の差異と小腸alkaline phosphataseの役割
- Budd-Chiari症候群における臨床所見と 血管造影所見との対比
- 蛋白漏出を認めた稀な限局性大腸リンパ管拡張症の1例
- 潰瘍性大腸炎における腸管外合併症の検討
- 直視下生検にて診断しえた高ガストリン血症随伴胃カルチノイドの1例と本邦症例の文献的検討
- 蛋白漏出性腸症, 高アミラーゼ血症を併発した Schönlein-Henoch 紫斑病の1例
- 凝固線溶系異常を呈し, 盲腸穿孔を生じた大腸クローン病の1症例
- タイトル無し
- A case of entercolitis with diffuse multiple aphthoid lesions in which non-caseous granulomas were demonstrated microscopically.
- A case of acute brucellosis associated with cholestatic jaundice.
- タイトル無し
- Acute gastric mucosal lesions induced by vasomotor derangement. Participation of xanthine oxidase and neutrophil-mediated oxidative stress.:Participation of xanthine oxidase and neutrophil-mediated oxidative stress
- 急性胃粘膜病変の局在と微小循環障害の関連
- :Effect of Colchicine on the Absorption of Long Chain Fatty Acids and the Role of Intestinal Alkaline Phosphatase