The Present status of Familial Polyposis of the Colon in Japan

概要

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On the 198 patients with multiple adenomatous polyps diffusely distributed throughout the colon, the informations of clinical and pathological features and their family history have been accumulated by means of the nationwide inquiry in two time (in 1961 and 1972) and direct examination at our hospital.The female case was less in population than the male (m:f=1:0.7) and younger in avarage age (35.7 years old and 30.4 years old). An age distribution curve showed a typical double peak pattern with a valley at the younger half of the thirty. Association of colonic cancer was detected increasingly higher incidence in older age: the highest of 92% at over the fifty and the lowest of 29% under the twenty.The composition of pedigree and family history are being ascertained by the clinical genetical practices.In 69 propositi with affected parents and/or siblings who have been found in the total of 157, the cumulative incidence of the affected siblings was 38.1% (135/354).The data will be contributable for further analysis of genetics of this disease and for early detection of the carrier and long term follow up of the patents.
財団法人日本消化器病学会の論文