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The proband was a female who was operated on twice, for cancer of. the sigmoid colon at age of 47 and rectal cancer at age of 53. Her mother died of gastric cancer at age of 60 and brother died also of cancers in the colon and prostate at age of 55. Since the feature of her present illness and family history included some of essential criteria for identification of non-polyposis hereditary large bowel cancer, her three sons were called up for colonic examination and a cancer was found in one of them.<BR>He was 31 years old and never had a medical consultation. Rectosigmoidscopy and barium enema revealed a diffuse elevated lesion with a shallow ulcer involving down to 10 cm from the anal berge. Low anterior resection. was performed. A lesion diffusely invol-ving in a length of 11 cm in the upper rectum showing a feature of linitis plastica.<BR>Histology was well differentiated adenocarcinoma, partly mixed. with poorly differenti-ated cells and gelatinous foci showing a schirous structure. The stage was Dukes A.<BR>His postoperative course was eventful and is working well at one and half year thenafter.<BR>Since linitis plastica type cancer of the colon and rectum is generally appreciated as of very poor prognosis, it was considered that rather early treatment in the present case was successfully made by an identification of the non-polyposis hereditary large bowel cancer.
日本大腸肛門病学会の論文