フェノール,P-クロルフェノールおよび2,4,5-トリクロルフェノールのトリ-,テトラ-,ペンタ-エチレングリコールエーテルの合成とその殺菌性

概要

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Tri-, tetra-, and pentaethyleneglycol ethers of phenol, p-chlorophenol, and 2, 4, 5-trichlorophenol were prepared and tested as the growth inhibiting agents against Staphylococcus aureus 209 P and Escherichia coli in order to study the effect of hydrophilic oxyethylene linkages.<BR>They were respectively prepared by the Williamson condensation of potassium salts of phenol, p-chlorophenol, and trichlorophenol with tri-, tetra- and penta-ethyleneglycol-monochlorides. The melting points, elemental analyses and infrared analyses of the products were presented. The inhibiting powers of those ethers against test microorganisms revealed that the introduction of oxyethylene radicals to phenols reduced their antimicrobial activities. Especially the activities of these ethyleneglycol ethers of non-chlorinated phenol were almost lost.<BR>The surface tensions of aq. solutions of the pentaethyleneglycol ethers were also determined and it was confirmed that the 2, 4, 5-trichlorophenol ether was surface active as much as the corresponding PCP ether.
日本油化学会の論文