チオエーテル結合を含むN-置換アミノ酸型両性界面活性剤の合成とその抗菌性

概要

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N-Substituted glycine-, alanine- and betaine-type amphoteric surfactants containing long chain alkylthio group were synthesized, and their growth inhibitory activities against Gram positive, Gram negative baccili and some fungi were studied. The effect of the alkylthio group on their antimicrobial and surface activities was compared to that of the alkoxy group of the corresponding N-substituted amino acid amphoterics containing alkoxy group. The obtained N-substituted amino acid amphoterics containing alkylthio group generally, have large antimicrobial powers and excellent surface activities except alanine type derivatives. Dibasic amino acid-type amphoterics having an alkylthio group in the molecule were also tested. Their antimicrobial activities were less than those of the corresponding monobasic amino acid-type amphoterics. Furthermore, N-substituted glycine- and alanine- type amphoteric surfactants, which contained the ether and thioether linkages in the long chain were synthesized and their antimicrobial and surface activities were studied. It is found that the antimicrobial powers of N-substituted amino acid type amphoterics containing alkoxy group is enhanced by introducing an additional thioether group in the molecule.<BR>The relative position of ether and thioether group apparently affected their antimicrobial activities.
社団法人日本油化学会の論文