Trichloroethylene毒性に関する実験的研究-2-Trichloroethylene暴露による血清中及び尿中代謝産物の経時的変化

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Dogs were exposed for one hour to trichloroethylene at concentrations of 700, 1, 500 and 2, 000ppm. Metabolite (trichloroethanol (F-TCE), trichloroacetic acid (TCA) and total trichloroethanol (T-TCE)) changes in serum and urine were measured from the beginning of exposure until one hour after termination. Particulary, in 700ppm exposure group, other dogs were exposed for two hours to trichloroethylene and these metabolites were mesured in urine and in serum. These two groups were compaired with each other.The results were as follows.1. Trichloroethylene metabolites in serum and in urine correlated significantly with trichloroethylene concentration, and with absorption by the lungs, respectively.2. Renal excretion rates of metabolites were T-TCE, TCA and F-TCE in order of highest to lowest.3. The percentage of trichloro-compounds in the urine to total trichloroethylene absorption by the lungs was about 0.7% at one hour following the termination of exposure.4. Ninety and 120 minutes of the beginning of exposure, trichloroethylene metabolites in serum and urine of the group being exposed were lower than those group where exposure had been terminated.
日本衛生学会の論文