1,1,1-Trichloroethaneによる心筋のEpinephrineに対する感作

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It is presumed that a part of mechanisms in the occurrence of ventricular arrhythmia or fibrillation in cases of 1,1,1-trichloroethane (1,1,1-TCE) intoxication is related to cardiac sensitization to epinephrine. Experiment was performed 1) to determine the threshold concentration of 1,1,1-TCE to produce cardiac sensitization, and 2) to clarify the pattern of this reaction. Mongrel dogs were anesthetized with intravenous administration of sodium pentobarbital at 25-30 mg/kg, and tracheal intubation was performed. Experiments were carried out under positive pressure ventilation. Epinephrine (5 μg/ml) was injected intravenously using drip method until bigeminy occurred on the electrocardiogram, and dose of epinephrine was measured by a drop counter. A constant concentration of 1,1,1-TCE was made by inside circuit vaporizer, and this was inhaled during a constant period, then epinephrine was injected until bigeminy occurred. Dose of epinephrine was compared before and after inhalation of 1,1,1-TCE. Appearance of cardiac sensitization by epinephrine was shown when bigeminy was induced by lesser dose of epinephrine compared to the dose before inhalation. The concentration of 1,1,1-TCE in inspired air was measured with gas chromatography. Inhalation of the fresh air was performed (control), the ratio of epinephrine after to before the injection of epinephrine being 1.11±0.037(Mean±S.E.). After inhalation of 1,1,1-TCE of which concentration was less than 4,900 ppm during 10 minutes, dose of epinephrine was not decreased compared that before inhalation. However, dose of epinephrine decreased when insprired concentration levels was more than 8,500 ppm. It is suggested that threshold of the cardiac sensitization may be 4,900 to 8,500 ppm during 10 minutes' inhalation. Significant correlation was observed between the concentration of 1,1,1-TCE in inspired air and the ratio of epinephrine after to before the inhalation. Increase in the product of concentration (6,900 to 69,000 ppm) and inhalation period (0.5 to 20 minutes) was accompanied with the gradually decreased ratio of epinephrine. This result suggests that cardiac sensitization to epinephrine is understood by a dose response relationship. In addition, ventricular fibrillation was induced by 4.73 μg/kg of epinephrine after inhalation of very high concentration (6.5%) lasting 1 minute.
社団法人日本産業衛生学会の論文
1982-09-20

1,1,1-Trichloroethaneによる心筋のEpinephrineに対する感作

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