1,1,1-Trichloroethaneの肺からの吸収及び排泄におよぼす諸要因の影響

概要

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To investigate 1, 1, 1-Trichloroethane absorption and excretion by the lungs, dogs were made to inhale 1, 1, 1-Trichloroethane under positive pressure ventilation. The concentrations of expired air and arterial blood were measured both during and after exposure.The results obtained were as follows.1. As the ventilation levels increased by a factor of three during and after exposure the absorption values increased by a factor of 1.7 and excretion values 2.2, if the ventilation levels were unchanged.2. If conditions remained the same, body weight effected of the absorption and excretion values during and after exposure to 1, 1, 1-Trichloroethane.3. If the conditions remained the same, arterial blood/expired air partition coefficients after exposure changed with variations in ventilation level, body weight or cardiac output.
日本衛生学会の論文