Trichloroethylene毒性に関する実験的研究-1-Trichloroethyleneの肺からの吸収及び排泄に関する研究

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In previous paper, the authors reported the uptake and excretion of 1, 1, 1-trichloroethane (1, 1, 1-TCE) by the lungs.In the present investigation, fifteen dogs were made to inhale trichloroethylene at concentrations of 700, 1500, 2000ppm. for one hour, and the changes in its concentrations in expired air, arterial blood and venous blood were measured from the beginning of exposure untill one hour after it had been terminated.The results were as follows1. The levels of cumulative intake of trichloroethylene after one hour were 54.6mg/kg for 700ppm., 94.0mg/kg for 1500ppm. and 136.7mg/kg for 2000ppm..2. The mean cumulative excretion ratio one hour after ward was 48% for the three exposure levels.3. The mean ratio of total absorption to total inspiration was 31% for the three levels.4. Using the above results, the authers examined the multiple regression equation using two independent variables (x) and (z) which were as follows.a) During the exposure period.Y1: Cumulative absorption (mg/kg).X1: Exposure duration (min.)Z1: Levels of the solvent per ambient air concentration (μg/ml).log Y1=-0.3375+0.7088 log X1+0.9438 log Z1b) During the post exposure period.Y2: Cumulative amounts of solvent excreted (mg/kg).X2: Time in minutes after exposure ended.Z2: Cumulative absorption when exposure ended (mg/kg).log Y2=-4.1709+0.6906 log X2+1.1470 log Z2It was assumed that both equations fit and were significant.
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