1,1,1-Trichloroethaneの肺からの吸収および排泄の実験的研究と動力学的検討

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Of fifteen dogs each five of them inhaled 1,1,1-trichloroethane (1,1,1-TCE) at the levels of 700, 1500, and 2,000 ppm respectively for one hour. Changes in 1,1,1-TCE concentrations in the expired air, arterial blood and venous blood of dogs were measured from the beginning of exposure until one hour after the end of exposure. The results obtained were as follows. 1. Cumulative uptakes of 1,1,1-TCE in one hour exposure were 27.3 mg/kg at 700ppm, 44.7 mg/kg at 1,500 ppm and 71.2 mg/kg at 2,000 ppm. 2. Excretion ratios of 1,1,1-TCE in hour after the exposure were 66-71% at all the three levels of exposure. 3. During the exposure, highly significant negative corrrelation was seen between arterial/venous blood concentration ratio and expired/inspired air concentration ratio. In the post-exposure period, highly significant positive correlations were seen between expired air concentration and venous or arterial blood concentration. 4. The mean ratio of the total absorption value to the total inspired value was 14% at all the three levels of exposure. 5. From these results, the authors examined the multiple regression equations with two independent variables x and z which are shown as follows. a) During the exposure period, Y_1: Cumulative absorption solvent by the dog (mg/kg) X_1: Time of exposure (min) Z_1: Level of the solvent value in the ambient air (μg/ml) logY_1=-0.526+0.622logX_1+0.905logZ_1 b) Post exposure period, Y_2: Cumulative excreted solvent value by the dog (mg/kg) X_2: Time after the end of exposure (min) Z_2: Cumulative absorbed solvent value by the dog at the end of exposure (mg/kg) logY_2=-2.300+0.609logX_2+0.858logZ_2 We assumed that both equations are very fit and signficant.
社団法人日本産業衛生学会の論文
1982-11-20

1,1,1-Trichloroethaneの肺からの吸収および排泄の実験的研究と動力学的検討

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