有機溶剤の胆汁中への排泄と血液中及び肝臓中溶剤濃度との関係

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Changes in organic solvents concentrations in blood, bile and liver and in serum GOT and GPT activities of dogs were measured two hours after the administration of six organic solvents.: 1, 1, 1-trichloroethane, 1, 1, 2-trichloroethane, trichloroethylene, tetrachloroethylene, toluene, m-xylene and controls. Five dogs were used as the intravenous administration for each solvent. The results obtained were as follows.1. Very small amounts of each solvent administrated were excreted into the bile within 2 hours.2. The unchanged solvent translation rate from the blood to the liver and from the liver to the bile was different for each solvent.3. Elevated serum GOT and GPT activities were recorded after the intravenous administration of 1, 1, 2-trichloroethane and tetrachloroethylene.
日本衛生学会の論文