リチウムの母仔間移行

概要

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Lithium salts are widely used in the treatment of psychotic patients, therefore, it is of significance whether lithium is able to cross the placental barrier and be transmitted to the fetus in pregnant women. The purpose of this paper is to demonstrate that lithium is transmitted to the fetus at a low level.Sixteen rats were given lithium in single doses of 4mg/kg daily by gastric incubation during gestation, days 1-10 or 10-19. This dose is approximately twice the therapeutic dosage used psychiatrically. All animals were sacrificed on day 11 or 20 of pregnancy.Lithium concentrations in maternal tissues (liver, kidney, brain, serum, blood cells), in the placenta, the fetus and the amniotic fluid were determined by flame or flameless atomic absorption spectrophotometry.Ten days after the termination of the drug, lithium concentrations in maternal and fetal tissues were the same as those for the control group. Lithium was rapidly absorbed from the gastrointestinal tract and transmitted from the mother to the fetuses were higher on day 11 than on day 20. The results thus indicate that lithium crosses the placental barrier but is inhibited to some degree in the last stages of pregnancy.
日本衛生学会の論文