微量カドミウム投与ラット骨組織の力学的強度変化-1-圧縮強度について

概要

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The present investigation aims at establishing the minimum dose of cadmium at which bone lesions can be caused, using the mechanical strength test as the determining factor. We examined the compressive strength of femurs of rats to which 0 (control group), 1, 5 or 10ppm cadmium respectively had been administered in drinking water over a four-week period. When a bone was compressed longitudinally to its axis, the ultimate compressive loads at the distal end and at the diaphysis were obtained. The ultimate loads were transformed into reduced compressive stresses by using either the femoral wet weight or the approximate diameter of the femur. From femoral wet weight, the compressive stresses significantly decreased in the case of the 10ppm Cd group, as compared with controls. However, compressive stresses from the approximate diameters of the femurs significantly decreased in the case of both the 5 and 10ppm groups, as compared with controls, and the dosage response relationship was clearly seen at the epiphyses.
日本衛生学会の論文