EFFECT OF GLYCYRRHIZIN ON THE SUPPRESSIVE ACTION OF CORTISONE ON THE PITUITARY ADRENAL AXIS

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概要

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• The effects of glycyrrhizin on the pituithry adrenal axis were studied. Isolated rat anterior pituitary glands were incubated with <SUP>14</SUP>C-phenylalanine and biosynthetic activity of corticotropin in the pituitary was estimated. The rate of incorporation of radioactivity from <SUP>14</SUP>C-phenylalanine into corticotropin fraction in the rat anterior pituitary was increased specifically by prior adrenalectomy. Cortisone treatment suppressed the increased <SUP>14</SUP>C-incorporation into the corticotropin fraction induced by prior adrenalectomy. However concomitant injections of glycyrrhizin blocked the inhibitory action of cortisone on <SUP>14</SUP>C-incorporation into the corticotropin fraction. Glycyrrhizin was also found to be antagonistic to the suppressive action of cortisone on compensatory adrenal hypertrophy in rats after unilateral adrenalectomy. Under condition of stress, glycyrrhizin was found to increase the inhibitory action of cortisone on adrenal ascorbic acid depletion. The possibility of distinguishing the secretory mechanism of corticotropin in the basal stage from that in the condition of stress and the mechanism of the inhibition of glycyrrhizin on the action of cortisone are discussed.

• 社団法人 日本内分泌学会の論文

著者

• Yamamura Yuichi

  Third Department of Internal Medicine, Osaka University Medical School

• KUMAGAI AKIRA

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• ASANUMA YOSHITSUGU

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• YANO SABURO

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• TAKEUCHI KAZUYUKI

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• MORIMOTO YASUHIKO

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• UEMURA TAIZO

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• YAMAMURA Yuichi

  Third Department of Internal Medicine, Medical School of Osaka University

• Kumagai A.

  Third Department of Internal Medicine, Osaka University

• YAMAMURA YUICHI

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

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