A Correlative Study on the Changes of Cardiac Dynamics and Myocardial Energy Liberation in Blood-Let Dogs
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概要
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Blood-letting of 450 to 1, 000ml with or without saline infusion was performed in dogs. In some dogs, right atrial pacing was carried out during blood-letting. Heart rate and isometric time-tension index were measured as the indicators of chronotropism and inotropism, respectively. After 60 min of blood-letting, dogs were sacrificed and mitochondria were isolated from the left ventricular myocardium. Mitochondrial respiration was measured polarographically and respiratory control index was calculated.As blood-letting advanced, the hearts revealed negative chronotropism with negative inotropism. Mitochondrial respiration was suppressed. When heart rate was forced to increase with atrial pacing, the hearts showed positive chronotropism with negative inotropism. Respiratory control index of mitochondria was deteriorated, showing uncoupling of oxidative phosphorylation.In consideration with our previous study on the ischemic heart, it is concluded that uncoupling of oxidative phosphorylation appeared in hypoxic myocardium when cardiac dynamics shifted to positive chronotropism with negative inotropism, though suppression of mitochondrial respiration was revealed when cardiac dynamics altered to negative chronotropism with negative inotropism.
- International Heart Journal刊行会の論文
著者
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Yamamura Yuichi
Third Department of Internal Medicine, Osaka University Medical School
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Ueno Teiichi
Third Dept. Of Intern. Med. Osaka Univ
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ISHIYAMA Taro
Third Dept. of Intern. Med., Osaka Univ. Med. School
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MORITA Yoshiharu
Third Dept. of Intern. Med., Osaka Univ. Med. School
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Tsukamoto Nozomu
Department of Intemal Medicine Nishinomiya,Municipal Central Hospital
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Ogura Kyoko
Third Dept. of Intern. Med.,Osaka Univ.
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Hatanaka Yoshie
Third Dept. of Intern. Med.,Osaka Univ.
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Tanimoto Takuji
Third Dept. of Intern. Med., Osaka Univ
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Morita Yoshiharu
The Third Department Of Internal Medicine Osaka University Medical School
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Hatanaka Yoshie
Third Dept. Of Intern. Med. Osaka Univ
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AZUMA Junichi
Third Department of Internal Medicine, Osaka University, School of Medicine
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ISHIYAMA Taro
Third Department of Internal Medicine, Osaka University Medical School
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ISHIYAMA Taro
Third Department of Internal Medicine, Osaka University, School of Medicine
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HATANAKA Yoshie
Third Department of Internal Medicine, Osaka University, School of Medicine
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HATANAKA Yoshie
Third Department of Internal Medicine, Osaka University Medical School
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UENO Teiichi
Third Department of Internal Medicine, Osaka University Medical School
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TSUKAMOTO Nozomu
Department of Internal Medicine, Nishinomiya City Central Hospital
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YAMAMURA Yuichi
Third Department of Internal Medicine, Osaka University, School of Medicine
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YAMAMURA YUICHI
Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University
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OGURA Kyoko
Third Department of Internal Medicine, Osaka University Medical School
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MORITA Yoshiharu
Third Department of Internal Medicine, Medical School of Osaka University
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MORITA Yoshiharu
Third Department of Internal Medicine, Osaka University, School of Medicine
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AZUMA Junichi
Third Department of Internal Medicine, Osaka University Medical School
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TANIMOTO Takuji
Third Department of Internal Medicine, Osaka University, School of Medicine
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TANIMOTO Takuji
Third Department of Internal Medicine, Osaka University Medical School
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