THE INFLUENCE OF ESTRADIOL-17β ON CORTISOL METABOLISM <I>IN VITRO</I>
スポンサーリンク
概要
- 論文の詳細を見る
1. The influence of estradiol-17β on cortisol metabolism was studied <I>in vitro</I> using the rat liver homogenate and microsome fraction.<BR>2. It was found in the experiments using homogenates that β<SUP>4</SUP>-3-ketone reduction of cortisol was considerably increased following the addition of a given amount of estradiol-17β to the medium and this effect of estradiol-17β became more pronounced under an anaerobic condition or in the presence of potassium cyanide.<BR>3. The stimulatory action of estradiol-17β on cortisol metabolism and its relation to TPNH-generating system were investigated in the purified enzyme system (24, 000×g supernatant fraction). It was found that estradiol-17β was able to replace glucose-6-phosphate system and no effect of estradiol-17β was observed in the presence of TPNH. Similar stimulatory effect of estradiol-17β was noted on aldosterone metabolism.<BR>4. Experiments on estrogen metabolism in microsome fraction of the rat liver showed evidence that the addition of cortisol with TPN increased the production of estrone from estradiol-17β.<BR>5. The results obtained suggest that estradiol-17β acts as a hydrogen donor to TPN to increase the reduction of A-ring of cortisol.
- 社団法人 日本内分泌学会の論文
著者
-
MATSUMOTO KEISHI
Department of Pathology, Osaka University Medical School
-
KUMAGAI AKIRA
Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University
-
YANO SABURO
Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University
-
NISHINO KAZUHIKO
Third Department of Internal Medicine, Medical School of Osaka University
-
TAKEUCHI NOZOMU
Third Department of Internal Medicine, Osaka University
-
UEDA HYO
Third Department of Internal Medicine, Osaka University
-
TAKEUCHI KAZUYUKI
Central Clinical Laboratory, Osaka University
-
Kumagai A.
Third Department of Internal Medicine, Osaka University
-
YANO SABURO
Third Department of Internal Medicine, Osaka University
-
MATSUMOTO KEISHI
Department of Pathology, Osaka University
関連論文
- CHANGES OF URINARY STEROIDS FOLLOWING MAJOR SURGICAL STRESS
- URINARY STEROIDS IN FIFTEEN CASES OF CONGENITAL VIRILIZING ADRENAL HYPERPLASIA
- 16α-HYDROXYLATION OF PREGNENOLONE BY HUMAN FETUS
- EFFECT OF GLYCYRRHIZIN ON THE SUPPRESSIVE ACTION OF CORTISONE ON THE PITUITARY ADRENAL AXIS
- AN INHIBITORY EFFECT OF GLYCYRRHIZIN ON METABOLIC ACTIONS OF CORTISONE
- THE PRODUCTION OF CORTICOIDS IN NORMAL AND PATHOLOGIC HUMAN ADRENAL SLICES AND INFLUENCES OF ACTH AND ANGIOTENSIN II ON CORTICOID-PRODUCTION
- STUDIES ON THE IN VITRO PRODUCTION OF ALDOSTERONE AND OTHER CORTICOIDS IN THE ADRENAL ADENOMA OF A PRIMARY ALDOSTERONISM
- THE INFLUENCE OF ESTRADIOL-17β ON CORTISOL METABOLISM IN VITRO
- 5α-Reduction of Testosterone in Vitro by Seminiferous Tubules, Prostate and Muscle from Immature Rats
- INFLUENCES OF SOME STEROIDS ON THE CORTICOSTERONE PRODUCTION BY RAT ADRENAL IN VITRO
- PROGESTINS IN THE OVARIAN VEIN BLOOD OF NONPREGNANT AND PREGNANT RABBITS BEFORE AND AFTER GONADOTROPIC STIMULATION
- STUDIES ON THE URINARY STEROIDS IN BILATERAL GYNECOMASTIA