INFLUENCES OF SOME STEROIDS ON THE CORTICOSTERONE PRODUCTION BY RAT ADRENAL <I>IN VITRO</I>

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概要

• 論文の詳細を見る

• 1. Glucocorticoids, cortisol and prednisolone, inhibited the ACTH effect <I>in vitro</I>. At the concentration of about 10<SUP>-5</SUP><I>M</I> of glucocorticoid, the ACTH effect was almost completely inhibited, but this inhibitory action was not observed below the concentration of 10<SUP>-6</SUP><I>M</I>. The inhibitory action on the ACTH effect of glucocorticoid could be removed by a previous addition of ACTH.<BR>2. Tetrahydrocortisol, methyltestosterone and estradiol-17β did not inhibit the ACTH effect. Estradiol-17β increased the production of corticosterone in an ACTH-free medium.<BR>3. It was suggested that the inhibitory action of glucocorticoid might be based on the result of inhibited metabolism of phosphorous in the adrenal cortex.<BR>4. The data obtained indicate a possibility that the inhibition of the pituitary adrenal system following the administration of corticoids occurs not only at the level of the pituitary but also at the level of the adrenal cortex.

• 社団法人 日本内分泌学会の論文

著者

• KUMAGAI AKIRA

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• YANO SABURO

  Third Department of Internal Medicine and Central Laboratory, Medical School of Osaka University

• NISHINO KAZUHIKO

  Third Department of Internal Medicine, Medical School of Osaka University

• TAKEUCHI KAZUYUKI

  Central Clinical Laboratory, Osaka University

• FUKUI S.

  Central Laboratory, Osaka University

• YANO SABURO

  Third Department of Internal Medicine, Osaka University

• WATANABE FUKUKO

  Central Laboratory, Osaka University

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• THE PRODUCTION OF CORTICOIDS IN NORMAL AND PATHOLOGIC HUMAN ADRENAL SLICES AND INFLUENCES OF ACTH AND ANGIOTENSIN II ON CORTICOID-PRODUCTION
• STUDIES ON THE IN VITRO PRODUCTION OF ALDOSTERONE AND OTHER CORTICOIDS IN THE ADRENAL ADENOMA OF A PRIMARY ALDOSTERONISM
• THE INFLUENCE OF ESTRADIOL-17β ON CORTISOL METABOLISM IN VITRO
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• INFLUENCES OF SOME STEROIDS ON THE CORTICOSTERONE PRODUCTION BY RAT ADRENAL IN VITRO

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