Effects of Prostaglandin E<SUB>1</SUB> and Indomethacin on ACTH, Prolactin, GH and LH from Rat Pituitary <I>in Vitro</I>
スポンサーリンク
概要
- 論文の詳細を見る
The effects of prostaglandin E<SUB>1</SUB> (PGE<SUB>1</SUB>) and indomethacin (IDM) on the release of several pituitary hormones from the rat pituitary were investigated <I>in vitro</I>.<BR>An addition of 2μg/m<I>l</I> of PGE<SUB>1</SUB> to the medium elicited the release of growth hormone (GH) and prolactin, but not of adrenocorticotropin (ACTH) and luteinizing hormone (LH).Although the addition of 1μg/m<I>l</I> of IDM alone resulted in no effect on the basal release of these hormones, IDM diminished the release of ACTH induced by crude rat hypothalamic extracts (HE) or lysine-8-vasopressin (LVP), and LH induced by HE or luteinizing hormone-releasing hormone (LH-RH).<BR>These findings implicate that a part of PGE<SUB>1</SUB> action might be a direct one on the pituitary gland and PGE<SUB>1</SUB> might release GH and prolactin, whereas IDM might have a direct action on the pituitary gland, and that blunt the release of these pituitary hormones induced by several stimuli.
- 社団法人 日本内分泌学会の論文
著者
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Yamane Yukio
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Takahara Jiro
The Third Department Of Internal Medicine School Of Medicine Okayama University
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HASHIMOTO KOZO
Third Department of Internal Medicine, Okayama University Medical School
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TAKAHARA JIRO
Third Department of Internal Medicine, Okayama University Medical School
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OFUJI TADASHI
Third Department of Internal Medicine, Okayama University Medical School
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HOSOGI HIDEMI
Third Department of Internal Medicine, Okayama University School of Medicine
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MORI MASAHIKO
Third Department of Internal Medicine, Okayama University School of Medicine
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OFUJI NOBUKO
Third Department of Internal Medicine, Okayama University School of Medicine
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YAMAUCHI JIRO
Third Department of Internal Medicine, Okayama University School of Medicine
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YAMANE YUKIO
Third Department of Internal Medicine, Okayama University School of Medicine
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