Suppression of Serum Growth Hormone Levels by Glucagon in Patients with Active Acromegaly

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概要

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• One mg of glucagon was given subcutaneously to eight patients with active acromegaly. Seven out of eight patients had a rapid decrease in serum growth hormone (GH) levels at 30 min after the glucagon injection. In two out of seven patients a rebound increase in serum GH following the early GH reduction was observed.<BR>On the other hand, oral administration of 50g glucose which caused a comparable increase in blood glucose to that after the glucagon injection elicited no early suppression in serum GH levels in the same patients. These data suggest that the inhibition of GH release induced by glucagon could not be related to the increase in blood glucose by glucagon.

• 社団法人 日本内分泌学会の論文

著者

• Takahara Jiro

  The Third Department Of Internal Medicine School Of Medicine Okayama University

• TAKAHARA JIRO

  3rd Department of Internal Medicine, Okayama University School of Medicine

• HOSOGI HIDEMI

  3rd Department of Internal Medicine, Okayama University School of Medicine

• YAMAUCHI JIRO

  3rd Department of Internal Medicine, Okayama University School of Medicine

• OGAWA NORIO

  3rd Department of Internal Medicine, Okayama University School of Medicine

• OFUJI TADASHI

  3rd Department of Internal Medicine, Okayama University School of Medicine

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• Hypothalamic Pituitary Adrenal Function in Patients with Anorexia Nervosa
• Suppression of Serum Growth Hormone Levels by Glucagon in Patients with Active Acromegaly
• Extra-Adrenal Action of Metyrapone upon Human Growth Hormone Secretion in Man

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