The Effect of Serotonin Agonist 1-(Trifluoromethylphenly)-piperazine on Corticotropin Releasing Factor and Arginine Vasopressin in Rat Hypothalamic Nuclei
スポンサーリンク
概要
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Effects of 1-(m-trifluoromethylphenyl)-piperazine, a serotonin agonist, were examined on rat plasma levels of adrenocorticotropin (ACTH) and arginine vasopressin (AVP), and on hypothalamic contents of corticotropin releasing factor (CRF) and AVP, to investigate the role of brain serotonin in ACTH regulation. Both plasma ACTH and AVP levels increased markedly 30 min after injection of the compound and were still elevated at 80 min. CRF and AVP contents in the median eminence decreased 30 min after injection but returned to the basal levels by 80 min. The AVP content in the supraoptic nucleus was elevated 80 min after injection.<BR>The CRF and AVP content did not significantly change in the paraventricular, suprachiasmatic and arcuate nuclei. Serotonin or 1-(m-trifluoromethylphenyl)-piperazine did not stimulate the release of ACTH in pituitary cell cultures. These results suggest that both CRF and AVP were secreted into the portal vessels by 1-(mtrifluoromethylphenyl)-piperazine to release ACTH from the anterior pituitary and that both the ACTH and AVP release were stimulated via the brain serotonergic mechanism.
- 社団法人 日本内分泌学会の論文
著者
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HASHIMOTO KOZO
Third Department of Internal Medicine, Okayama University Medical School
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OHNO NORIHITO
Third Department of Internal Medicine, Okayama University Medical School
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KAGEYAMA JINGO
Third Department of Internal Medicine, Okayama University Medical School
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AOKI YOSHIYUKI
Third Department of Internal Medicine, Okayama University Medical School
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TAKAHARA JIRO
Third Department of Internal Medicine, Okayama University Medical School
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MURAKAMI KAZUHARU
Third Department of Internal Medicine, Okayama University Medical School
関連論文
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