ACTH Release in Pituitary Cell Cultures. Effect of Neurogenic Peptides and Neurotransmitter Substances on ACTH Release induced by Hypothalamic Corticotropin Releasing Factor (CRF)

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of various neurogenic peptides and neurotransmitter substances on the release of ACTH induced by hypothalamic corticotropin releasing factor (HYCRF) were investigated using monolayer cultured anterior pituitary cells. Test substances were given in combination with 0.05-0.1 hypothalamic extract (HE)/m<I>l</I>, because HE evoked a significant ACTH release and a linear dose response relationship was demonstrated sequentially between 0, 0165 HE/m<I>l</I> and 0.5HE/m<I>l</I>. Relatively high doses of lysine-vasopressin showed a slight additive effect onl the release of ACTH induced by 0.1HE/m<I>l</I>. Leu-enkephalin, dopamine, prostaglandin E<SUB>1</SUB> and E<SUB>2</SUB> slightly reduced the release of ACTH induced by HY-CRF, but the inhibitory effect of these substances were not dose-related. Other tested substances including luteinizing hormone releasing hormone, thyrottopin releasing hormone, somatostatin, melanocyte stimulating hormone release inhibiting factor, β-endorphin, neurotensin, substance P, vasoactive intestinal polypeptide, angiotensin II, norepinephrine, serotonin, acetylcholine, histamine and γ-amino butyric acid showed neither agonistic nor antagonistic effect on the release of ACTH induced by HY-CRF. These results indicate that the release of ACTH is controlled specifically by HY-CRF and corticosterone, and modified slightly by some other substances such as vasopressin and prostaglandins, and that the effect of most other neurogenic peptides and neurotransmitter substances is negligible or non-physiological at the pituitary level.

• 社団法人 日本内分泌学会の論文

著者

• HASHIMOTO KOZO

  Third Department of Internal Medicine, Okayama University Medical School

• YUNOKI SHO

  Third Department of Internal Medicine, Okayama University Medical School

• TAKAHARA JIRO

  Third Department of Internal Medicine, Okayama University Medical School

• OFUJI TADASHI

  Third Department of Internal Medicine, Okayama University Medical School

関連論文

• Characterization of Corticotropin Releasing Factor (CRF) and Arginine Vasopressin in Median Eminence Extracts on Sephadex Gel-filtration
• ACTH Release in Pituitary Cell Cultures. Effect of Neurogenic Peptides and Neurotransmitter Substances on ACTH Release induced by Hypothalamic Corticotropin Releasing Factor (CRF)
• Plasma Immunoassayable ACTH Levels during and after Hydrocortisone Infusion in Patients with Cushings Disease
• The Pituitary ACTH, GH, LH, FSH, TSH and Prolactin Reserves in Patients with Cushings Syndrome
• The Effect of Serotonin Agonist 1-(Trifluoromethylphenly)-piperazine on Corticotropin Releasing Factor and Arginine Vasopressin in Rat Hypothalamic Nuclei
• Effects of Prostaglandin E1 and Indomethacin on ACTH, Prolactin, GH and LH from Rat Pituitary in Vitro
• Hypothalamic Pituitary Adrenal Function in Patients with Anorexia Nervosa
• Direct Inhibitions of Basal and Arginine-Induced Plasma Gastrin Secretion by Somatostatin in Anesthetized Dogs
• Effect of Synthetic Corticotropins on Human Growth Hormone Secretion
• Influence of synthetic thyrotropin-releasing hormone tartrate monohydrate on plasma gonadotropin concentration of normal males.

スポンサーリンク