Influence of synthetic thyrotropin-releasing hormone tartrate monohydrate on plasma gonadotropin concentration of normal males.
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概要
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Synthetic thyrotropin-releasing hormone (TRH) tartrate monohydrate was administered by rapid intravenous injection to nine normal males. Plasma thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured before and at selected periods after TRH injection. The mean plasma TSH value immediately prior to TRH injection was 3.5μU/m<I>l</I> and the level 15 min after injection was 14.8μU/m<I>l</I>. The mean plasma LH value immediately prior to TRH injection was 8.0mIU/m<I>l</I> and the level 15 min after injection was 15.0 mIU/ ml. The latter elevation was statistically significant (p<0.01), although it was just above the upper normal range. The mean plasma FSH value immediately prior to TRH injection was 7.7 mIU/m<I>l</I>, and a significant difference was not observed after TRH administration. These results revealed that synthetic TRH tartrate monohydrate influenced the release of LH from the anterior pituitary.
- 社団法人 日本内分泌学会の論文
著者
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TAKAHARA JIRO
Third Department of Internal Medicine, Okayama University Medical School
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OFUJI NOBUKO
Third Department of Internal Medicine, Okayama University School of Medicine
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Miyoshi Masanori
Third Department of Internal Medicine, Okayama University School of Medicine
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- Influence of synthetic thyrotropin-releasing hormone tartrate monohydrate on plasma gonadotropin concentration of normal males.