Specific Binding of Prolactin to the Mammary Gland and Lactose Synthesis in Pregnant Rats After Removal of Ovaries or Ovaries and Adrenals
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概要
- 論文の詳細を見る
Ovariectomy performed at mid pregnancy increased the specific binding of <SUP>125</SUP>I-prolactin to the mammary gland (expressed as cpm/mg DNA) in rats 40hr after the operation. When adrenals were removed simultaneously at the time of ovariectomy, no increase in the specific binding was observed. An appreciable amount of lactose was found in all mammary glands of ovariectomized-adrenalectomized animals, though the content was less than half of that of the ovariectomized animals. The plasma level of prolactin in ovariectomized and ovariectomized-adrenalectomized rats was slightly higher than that in sham operated control rats, though the differences were not statistically significant. These results seem to indicate that the adrenal gland is necessary for the induction of the site of specific binding of prolactin in the mammary gland of the rat and that an increase in the circulating levels of prolactin does not seem to play an essential role in the initiation of milk synthesis in this species.
- 社団法人 日本内分泌学会の論文
著者
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YOKOYAMA Akira
Faculty of Pharmaceutical Sciences, Kyoto University
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Ota Katuaki
Faculty Of Agriculture Shinshu University
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Harigaya Toshio
Faculty Of Agriculture Meiji University
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KOHMOTO KAORU
Faculty of Agriculture, University of Tokyo
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YOKOYAMA AKIRA
Faculty of Agriculture, Nagoya University
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HARIGAYA TOSHIO
Faculty of Agriculture, University of Tokyo
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